pyrophosphorylysis

English

Noun

pyrophosphorylysis (plural pyrophosphorylyses)

The cleavage of a nucleoside from a nucleotide by breaking the bond to the phosphate group by a reaction with pyrophosphorylase.
- 1986, Patrick Sai-Cheong Leung, Cloning of the Salmonella Typhimurium LT2 Glycogen Biosynthetic Genes:
  The enzyme preparations were assay for ADPglucose pyrophosphorylase activity in the pyrophosphorylysis direction and were diluted to 0.5 units per ml with 50 mM Tris-HCl, pH 8.0, containing O. l mg/ml of bovine plasma pyrophosphorylase.
- 2002, Advances in Virus Research - Volume 58, page 170:
  Increased pyrophosphorylysis means that newly incorporated nucleotides, including potentially chain-terminating nucleotide analogues, are excised at a higher rate.
- 2017, Douglas L. Mayers, ‎Jack D. Sobel, ‎Marc Ouellette, Antimicrobial Drug Resistance, →ISBN:
  Although the DKAs and dihydroxypyrimidines can compete with nucleosides for binding to the active site, these compounds inhibit the pyrophosphorylysis (excision) of strand-terminating nucleosides once they are incorporated into the nascent HCV RNA.

单词	pyrophosphorylysis
释义	pyrophosphorylysis English Noun pyrophosphorylysis (plural pyrophosphorylyses) The cleavage of a nucleoside from a nucleotide by breaking the bond to the phosphate group by a reaction with pyrophosphorylase. 1986, Patrick Sai-Cheong Leung, Cloning of the Salmonella Typhimurium LT2 Glycogen Biosynthetic Genes: The enzyme preparations were assay for ADPglucose pyrophosphorylase activity in the pyrophosphorylysis direction and were diluted to 0.5 units per ml with 50 mM Tris-HCl, pH 8.0, containing O. l mg/ml of bovine plasma pyrophosphorylase. 2002, Advances in Virus Research - Volume 58, page 170: Increased pyrophosphorylysis means that newly incorporated nucleotides, including potentially chain-terminating nucleotide analogues, are excised at a higher rate. 2017, Douglas L. Mayers, ‎Jack D. Sobel, ‎Marc Ouellette, Antimicrobial Drug Resistance, →ISBN: Although the DKAs and dihydroxypyrimidines can compete with nucleosides for binding to the active site, these compounds inhibit the pyrophosphorylysis (excision) of strand-terminating nucleosides once they are incorporated into the nascent HCV RNA.
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