nondisjunction
English
Etymology
non- + disjunction
Noun
nondisjunction (plural nondisjunctions)
- (genetics) The failure of chromosome dyads or tetrads to separate properly during meiosis or mitosis.
- 2004 December 22, Yankai Xia, Senping Cheng, Qian Bian, Lichun Xu, Michael D. Collins, Hebron C. Chang, Lin Song, Jiayin Liu, Shoulin Wang, and Xinru Wang, “Genotoxic Effects on Spermatozoa of Carbaryl-Exposed Workers”, in Toxicological Sciences, volume 85, number 1, archived from the original on 24 December 2022, retrieved 24 December 2022:
- Different exogenous agents may interfere with the normal disjunction of sister chromosomes during meiosis and increase the frequency of aneuploid sperm, as demonstrated in mice treated with aneugens and men treated with anticancer agents. Although not all germ cells achieve maturity, the close correlation of chromosome nondisjunction in spermatogenesis with genotoxic outcomes indicates that the investigation for aneuploidy in a large sample of aneugen-exposed workers is significant.
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Derived terms
- nondisjunctional
- nondisjunctionally
Related terms
- disjunction
- nondisjunct
- nondisjunctive
See also
nondisjunction on Wikipedia.Wikipedia