myddosome

English

myddosome (plural myddosomes)

A complex of signalling proteins that has a role in the immune response
- 2016 January 12, “Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice”, in PLOS ONE‎, DOI:10.1371/journal.pone.0146326:
  This signaling complex, the so-called myddosome, assembles in a hierarchical manner so that IRAKs can associate with tumor necrosis factor receptor-associated factor 6 (TRAF6), which, via a complex signaling cascade, ultimately enables NF-κB to translocate into the nucleus where it regulates gene transcription.

单词	myddosome
释义	myddosome English Noun myddosome (plural myddosomes) A complex of signalling proteins that has a role in the immune response 2016 January 12, “Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice”, in PLOS ONE‎, DOI:10.1371/journal.pone.0146326: This signaling complex, the so-called myddosome, assembles in a hierarchical manner so that IRAKs can associate with tumor necrosis factor receptor-associated factor 6 (TRAF6), which, via a complex signaling cascade, ultimately enables NF-κB to translocate into the nucleus where it regulates gene transcription.
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