mismethylate

English

Etymology

mis- +‎ methylate

Verb

mismethylate (third-person singular simple present mismethylates, present participle mismethylating, simple past and past participle mismethylated)

To methylate incorrectly.
- 1994, A. Ian Scott, “The discovery of nature's pathway to vitamin B12. A 25 year Odyssey”, in Tetrahedron, volume 50, number 47:
  We did find that one of tbe Salmonella genes, cbiF, was capable of 'mismethylating' precorrin-3 at the 1 l-position, ie out of the natural order, to yield a tetramethyl pyrrocorphin
- 2012, Karl Kadish, ‎Kevin M. Smith, ‎Roger Guilard, The Porphyrin Handbook, page 217:
  CysG is a homodimer with a subunit M_r of 50,000, which, in addition to catalyzing methylation at C-2 and C-7, can also mismethylate precorrin 2 at C-12 to afford a trimethylpyrrocorphin derailment product.
- 2012, Jan Philip Wurm, Marco Griese, Ute Bahr, Martin Held, Alexander Heckel, Michael Karas, Jörg Soppa, Jens Wöhnert, “Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”, in RNA:
  M. jannaschii Nep mismethylates T-arm resembling RNAs.
- 2015, Robert A. Meyers, Synthetic Biology, page 412:
  Biosynthesis of Mismethylated Analogs of Cobalamin

单词	mismethylate
释义	mismethylate English Etymology mis- +‎ methylate Verb mismethylate (third-person singular simple present mismethylates, present participle mismethylating, simple past and past participle mismethylated) To methylate incorrectly. 1994, A. Ian Scott, “The discovery of nature's pathway to vitamin B12. A 25 year Odyssey”, in Tetrahedron, volume 50, number 47: We did find that one of tbe Salmonella genes, cbiF, was capable of 'mismethylating' precorrin-3 at the 1 l-position, ie out of the natural order, to yield a tetramethyl pyrrocorphin 2012, Karl Kadish, ‎Kevin M. Smith, ‎Roger Guilard, The Porphyrin Handbook, page 217: CysG is a homodimer with a subunit M_r of 50,000, which, in addition to catalyzing methylation at C-2 and C-7, can also mismethylate precorrin 2 at C-12 to afford a trimethylpyrrocorphin derailment product. 2012, Jan Philip Wurm, Marco Griese, Ute Bahr, Martin Held, Alexander Heckel, Michael Karas, Jörg Soppa, Jens Wöhnert, “Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”, in RNA: M. jannaschii Nep mismethylates T-arm resembling RNAs. 2015, Robert A. Meyers, Synthetic Biology, page 412: Biosynthesis of Mismethylated Analogs of Cobalamin
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