macrodose

macrodose

English

Etymology

macro- +‎ dose; contrast microdose.

Noun

macrodose (plural macrodoses)

1. A relatively large dose of (something, such as a drug or radiation), particularly as contrasted with a microdose.
   • 2002, H. Zaidi, G Sgouros, Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine, CRC Press (→ISBN)

     Here macrodose is defined as the average dose for a large-size object such as a liver or a tumour.

   • 2019, Paul G. Pearson, Larry C. Wienkers, Handbook of Drug Metabolism, Third Edition, CRC Press (→ISBN), page 702:

     The mass of non-radiolabeled dose in the total mass administered is selected to meet the aims of the study. The non-radiolabeled dose could be a macrodose (> 100 μg), in designs defined herein as “macrodose with microtracer” studies.

   • 2010, Jan Riordan, Karen Wambach, Breastfeeding and Human Lactation, Jones & Bartlett Learning (→ISBN), page 139:

     This is the equivalent of nearly 7 quarts per day for an adult—truly a macrodose! Vomiting, diarrhea, colic, and occult bleeding are symptoms of allergy. It also affects the respiratory tract (runny nose, cough, asthma) and the skin […]

Verb

macrodose (third-person singular simple present macrodoses, present participle macrodosing, simple past and past participle macrodosed)

1. To take a relatively large dose of (something, particularly a drug), particularly as contrasted with microdosing.
   • 2002, Irwin M. Siegel, MD, All About Joints: How to Prevent and Recover from Common Injuries, Demos Medical Publishing (→ISBN), page 16:

     Much less expensive than either is macrodosing with vitamins C, D, and E, which has been shown to be beneficial in slowing the progression of osteoarthritis of the knee.

   • 2019, Michael J. Winkelman, Ben Sessa MD, Advances in Psychedelic Medicine: State-of-the-Art Therapeutic Applications, ABC-CLIO (→ISBN), page 330:

     (Gasser et al., 2014) While this may have been a factor in our respondents' experiences, we did not ask them if they had macrodosed during their microdosing period.

   • 2020, Rob Doyle, Threshold, Bloomsbury Publishing USA (→ISBN)

     'In which case,' I'd pointed out, 'you're not microdosing at all, you're macrodosing'