hyperexpression

hyperexpression

English

Etymology

hyper- +‎ expression

Noun

hyperexpression (uncountable)

1. (genetics) overexpression
2. (genetics) Excessive expression
   • 2015 July 25, Ji Hyun Sim et al., “Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus”, in Arthritis Research & Therapy‎, volume 17, DOI:10.1186/s13075-015-0687-1:

     Since IL-10 and deficient co-stimulatory molecule expression appear to be a novel mechanism of self-tolerance employed by the pre-naïve B cells, a defect in pre-naïve B-cell functions could lead to a break in self-tolerance, especially in the SLE milieu, where expansion of the pre-naïve B cells has been found [ 3, 4 ], and the immune system is intensely activated as evidenced by elevated B cell-activating factor (BAFF) levels, hyperexpression of CD40L on T cells, and/or increased levels of certain cytokines such as IL-21 [ 50 – 53 ].