glucocorticoid receptor

English

Noun

glucocorticoid receptor (plural glucocorticoid receptors)

(biochemistry) A protein found in multiple forms within cells, which binds glucocorticoids and subsequently influences gene transcription.
- 1972 Levinson, B. B.; Baxter, J. D.; Rousseau, G. G.; Tomkins, G. M. "Cellular site of glucocorticoid-receptor complex formation." Science 175, no. 18 (14 January 1972): 189–190, http://www.sciencemag.org/cgi/content/abstract/175/4018/189 .
  The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials.
- 2009 Zimmer, Carl. "Can Evolution Run in Reverse? A Study Says It’s a One-Way Street," New York Times, 28 September 2009 [cited 18 December 2009], Science section, online edition, http://www.nytimes.com/2009/09/29/science/29evol.html.
  They studied a protein called a glucocorticoid receptor that helps humans and most other vertebrates cope with stress by grabbing a hormone called cortisol and then switching on stress-defense genes.

Synonyms

GCCR
GCR
GR
GRL

Hypernyms

nuclear hormone receptor

Hyponyms

GR-alpha, GR-α
GR-beta, GR-β
GR-gamma

References

Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 138040: 15 September 2009: . World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/ (specific entry archived at https://www.webcitation.org/5m7tIkXcj?url=http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138040, 18 December 2009).
Nussey, S. S. and Whitehead, S. A. The adrenal gland. In: Bosher, Andrea. Endocrinology: An Integrated Approach. Oxford, UK: BIOS Scientific Publishers; 2001 [cited 18 December 2009]. Available from: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A442#A468 .

单词	glucocorticoid receptor
释义	glucocorticoid receptor English Noun glucocorticoid receptor (plural glucocorticoid receptors) (biochemistry) A protein found in multiple forms within cells, which binds glucocorticoids and subsequently influences gene transcription. 1972 Levinson, B. B.; Baxter, J. D.; Rousseau, G. G.; Tomkins, G. M. "Cellular site of glucocorticoid-receptor complex formation." Science 175, no. 18 (14 January 1972): 189–190, http://www.sciencemag.org/cgi/content/abstract/175/4018/189 . The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials. 2009 Zimmer, Carl. "Can Evolution Run in Reverse? A Study Says It’s a One-Way Street," New York Times, 28 September 2009 [cited 18 December 2009], Science section, online edition, http://www.nytimes.com/2009/09/29/science/29evol.html. They studied a protein called a glucocorticoid receptor that helps humans and most other vertebrates cope with stress by grabbing a hormone called cortisol and then switching on stress-defense genes. Synonyms GCCR GCR GR GRL Hypernyms nuclear hormone receptor Hyponyms GR-alpha, GR-α GR-beta, GR-β GR-gamma References Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 138040: 15 September 2009: . World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/ (specific entry archived at https://www.webcitation.org/5m7tIkXcj?url=http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138040, 18 December 2009). Nussey, S. S. and Whitehead, S. A. The adrenal gland. In: Bosher, Andrea. Endocrinology: An Integrated Approach. Oxford, UK: BIOS Scientific Publishers; 2001 [cited 18 December 2009]. Available from: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&part=A442#A468 .
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