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单词 ganetespib
释义

ganetespib

English

Noun

ganetespib (uncountable)

  1. A triazolone, derived from resorcinol, that inhibits an oncogenic molecular chaperone
    • 2015 October 31, “Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants”, in PLOS ONE, DOI:10.1371/journal.pone.0141786:
      In this report, we compare the relative interaction strength of both HSP90α and HSP90β with the transcription factors HSF1 and HIF1α, the kinases ERBB2 and MET, the E3-ubiquitin ligases KEAP1 and RHOBTB2, and the HSP90 inhibitors geldanamycin and ganetespib.
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