craniorachischisis
English
Etymology
cranio- + rachischisis
Noun
craniorachischisis (plural craniorachischises)
- (pathology) A defect of the neural tube in which both the brain and spinal cord are left open
- 2015, Hernando R. Alvis-Miranda et al., “Iniencephaly: Case Report”, in Journal of Pediatric Neurosciences, volume 10, DOI: :
- The neural tube closure occurs around day 28 after conception; its closure failure may result in a defect that can range from anencephaly, incompatible with life, to small meningoceles.[ 1 ] The definition of neural tube defects (NTD) include anencephaly, craniorachischisis, iniencephaly, meningocele, meningomyelocele, and encephalocele, but not isolated findings of hydrocephalus or spina bifida oculta.[ 1 ] Iniencephaly, from the ancient Greek “inion” meaning “nape of the neck”, had its first report by Saint-Hilaire in 1836,[ 2 ] is characterized by a variable defect of the occipital bone, resulting in a large foramen magnum; partial or total absence of the cervical and thoracic vertebrae with irregular melting of those present, accompanied by incomplete closure of arcs and/or vertebral bodies, marked lordosis, hyperextension of the cervicothoracic spine; and a face deflected up.[ 3 ] The incidence is about 1:1000–1:2000 births,[ 4 ] then is a pretty rare NTD.
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